FEATURES

FAMILY

DESCRIPTION

Also known as PHKG2_HUMAN, PHKG2. Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PHKG2

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Mutations

Mutation(s) distribution

Mutations table

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