FEATURES

FAMILY

DESCRIPTION

Also known as RAD53_YEAST, RAD53, MEC2, SAD1, SPK1. Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1. Interacts with PIN4.

Also known as RAD53_YEAST, RAD53, MEC2, SAD1, SPK1. Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents ...

EXTERNAL LINKS

uniprot
enzyme classification

RAD53

Mutations

Mutation(s) distribution

Mutations table