FEATURES

FAMILY

DESCRIPTION

Also known as HRH2_HUMAN, HRH2. The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HRH2

Histamine H2 receptor

HRH2

Molecular Synopsis