FEATURES

FAMILY

DESCRIPTION

Also known as 5HT1D_HUMAN, HTR1D, HTR1DA, HTRL. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. Homodimer. Heterodimer with HTR1B.

Also known as 5HT1D_HUMAN, HTR1D, HTR1DA, HTRL. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and ...

EXTERNAL LINKS

HTR1D

Mutations

Mutation(s) distribution

Mutations table