FEATURES

FAMILY

DESCRIPTION

Also known as TTBK2_HUMAN, TTBK2, KIAA0847. Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Interacts with CEP164.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TTBK2

Mutations

Mutation(s) distribution

Mutations table