FEATURES

FAMILY

DESCRIPTION

Also known as CLTR2_HUMAN, CYSLTR2, CYSLT2, CYSLT2R. Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CYSLTR2

Cysteinyl leukotriene receptor 2

CYSLTR2

Molecular Synopsis