FEATURES

FAMILY

DESCRIPTION

Also known as CLTR1_HUMAN, CYSLTR1, CYSLT1. Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CYSLTR1

Cysteinyl leukotriene receptor 1

CYSLTR1

Molecular Synopsis