FEATURES

FAMILY

DESCRIPTION

Also known as PD2R2_HUMAN, PTGDR2, CRTH2, DL1R, GPR44. Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTGDR2

Mutations

Mutation(s) distribution

Mutations table