Selfish really. Cancer research labs across the world have shut down. Recruitment of new cancer patients to innovative, potentially life-saving clinical trials has all but stopped, cancer referrals and diagnoses have plummeted. We have to do something to re-instate our battle against cancer in full....
An snapshot of interventional clinical trials for Covid-19, SARS and MERS in clinicaltrials.gov at the end of April 2020 produces 528 non-vaccine clinical trials. . The vast majority (>500) of these are directed at CoViD-19. Here, existing therapies are being trialled in one of these Coronaviruses to treat the disease and/or alleviate the symptoms of the disease. level classification of the therapies sheds light on the key therapeutic approaches being explored in these diseases:...
3D structures are a powerful tool in understanding the molecular mechanisms of disease and the design and development of new drugs. canSAR-3D, the 3D structural component of canSAR, use artificial intelligence approaches to identify and predict the ‘ligandability’ (the propensity of a protein to bind a drug-like small molecule) of proteins with known 3D structure. We map potential cavities and assess 3D-ligandability for all proteins released in the Protein Data Bank automatically update these in Coronavirus canSAR on a weekly basis. ...